Does P-glycoprotein Predict Response to Chemotherapy?
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چکیده
منابع مشابه
Does P-glycoprotein predict response to chemotherapy?
Why some cancers are curable by chemotherapy while most are not is an enigma and a major challenge for cancer researchers. The use of anticancer drugs in appropriate dosages and combinations has improved response rates and prolonged life. Yet, it is not uncommon for a patient to have a relapse during a course of chemotherapy that was initially successful. The discovery more than a decade ago th...
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A case of invasive drug resistant thymoma, expressing P-glycoprotein, which showed noticeable clinical response to chemotherapy and the multidrug resistance modulating agents cyclosporin and quinine is reported. A 46 year old man presented with severe left shoulder pain and a diagnosis of invasive lymphoepithelial thymoma was made following chest x ray and a computed tomography scan. The patien...
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BACKGROUND Fewer than 20% of patients with bone cancer who are treated with surgery alone are cured. Even with the best current treatment, surgery combined with chemotherapy, only 60%-80% of patients with nonmetastatic bone cancer and 10% of patients with metastatic bone cancer are cured. Thus far, the reason for treatment failure in the nonresponding subset has not been identified. It has been...
متن کاملLack of correlation of P-glycoprotein expression with response to MIC chemotherapy in oesophageal cancer.
The multidrug resistance gene product P-glycoprotein (P-GP) was assessed immunohistochemically (by antibody JSB-1) in biopsy specimens from 27 oesophageal squamous carcinomas and 10 adenocarcinomas before treatment with mitomycin, ifosfamide and cisplatin (MIC). Tumours were assessed following treatment and correlation with response sought. Of the squamous carcinomas, 74% (20/27) responded to M...
متن کاملDoes color Doppler ultrasound vascularity predict the response to neoadjuvant chemotherapy in breast cancer?
OBJECTIVES To assess the proportions of response to neoadjuvant chemotherapy of breast cancer according to color Doppler ultrasound vascularity patterns. MATERIAL AND METHOD Prospective evaluation using gray scale and color Doppler ultrasound for number of vessels and feeding appearances of tumors as well as the changes in tumor sizes at before and after chemotherapy in 69 breast cancer patie...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1989
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/81.2.84